The Common Gene Variation That Might Be Affecting Your Folate Intake

According to Psychology Today, 30-50% of all people carry a gene mutation called methylenetetrahydrofolate reductase (MTHFR) and don't even know it1.

The MTHFR gene instructs your body to make an enzyme called methylenetetrahydrofolate reductase. MTHFR plays a central role in converting folate into the active form (vitamin B9) that is found circulating in your blood. This form of folate is then utilized in the process of lowering homocysteine levels in your body. Maintaining appropriate levels of homocysteine is important in the prevention of chronic diseases such as coronary artery disease (CAD), stroke, Alzheimer’s, and autism.

There can be one mutation (heterozygous) or two mutations (homozygous), which are passed down from parent to child. The more variations you have, the more issues your body will have with methylating.

An MTHFR gene mutation may change the way you metabolize and convert nutrients from your diet into active vitamins, minerals, and proteins your body can use. This genetic mutation may also affect hormone and neurotransmitter levels, brain function, digestion, cholesterol levels, and more.

Common Symptoms of MTHFR Gene Mutation

MTHFR mutations affect everyone differently, and symptoms can vary from long-term health issues to hardly any noticeable changes in overall health:

High Homocysteine Levels: Poor methylation leads to high levels of homocysteine, an amino acid. High levels of homocysteine are linked to increased risk of heart attacks and stroke.

Folate Deficiency: If you suffer from chronic fatigue, feel light-headed, or forgetful it could be due to a folate deficiency. MTHFR enzyme is vital to convert folic acid to folate in the body. A folate deficiency may be due to an MTHFR mutation2.

Fertility Issues: Folate metabolism is crucial for ovarian function and embryo formation throughout pregnancy. If folate levels suffer, it may affect your ability to conceive a baby. If you suffer from unexplained infertility problems MTHFR mutation may be one of the reasons3. Women with a history of more than one miscarriage may have an MTHFR mutation problem.

Check with your doctor if you are concerned about having MTHFR gene mutation.

Folate in Supplements

You need B vitamin supplements that provide Quatrefolic 5-methyltetrahydrofolate (5-MTHF), the active form. Regular folic acid supplements and folate from foods are not biologically active. Your body needs to convert it to the metabolically active form (5-MTHF) for use, a process that involves many steps and enzymes. The conversion to the active form never happens in those with the MTHFR gene mutation and consequently suffer from a deficiency.

The Quatrefolic 5-MTHF is a form of folate that your body easily recognizes and uses4. Plus, because of its structure, there is no need for the body to convert it to the active form. When your cells receive active folate as Quatrefolic 5-MTHF it directly passes your stomach and reaches your small intestine. This facilitates better access to the blood and thereby improving bioavailability.

NATURELO's Multivitamins contain MTHFR friendly folate in the form of Quatrefolic 5-methyltetrahydrofolate (5-MTHF).

NATURELO's Plant-based B complex vitamins contain the active forms of Folate (5-Methyl Folate), B6 (P-5-P), and B12 (Methylcobalamin).


1. A Genetic Mutation That Can Affect Mental & Physical Health, Sep 05, 2014 

2. Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency, 2015 Aug 10;7(8):6670-87. doi: 10.3390/nu7085303 

3. Folate Metabolism and Human Reproduction, 2014 Sep; 74(9): 845–851 

4. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics, 2010 Aug;49(8):535-48. doi: 10.2165/11532990-000000000-00000